miR‑583 inhibits the proliferation and invasion of prostate cancer cells by targeting JAK1

Prostate cancer (PCa) is a leading cause for death in men and the most commonly diagnosed malignancy globally. MicroRNA (miR)‑583 expression levels have been discovered to be downregulated recurrent PCa samples compared with non‑recurrent cases. However, precise functions pathogenic mechanism of miR‑583 development are vague, thus aim present study was investigate these. The Janus kinase 1 (JAK1) tissues cell lines were analyzed using reverse transcription‑quantitative PCR western blotting. protein phosphorylated (p)‑STAT3 STAT3 also effects JAK1 on proliferation invasion determined MTT Transwell assays, respectively. binding interaction between 3'‑untranslated region predicted by TargetScan, further validated dual luciferase reporter assays lines. results revealed that downregulated, while those upregulated (DU145 PC3). transfection mimic inhibited invasion, as well downregulating p‑STAT3 DU145 PC3 These partially abolished following overexpression JAK1. Moreover, identified target gene negatively correlated tissues. In conclusion, findings suggested may inhibit cells targeting JAK1, providing novel therapeutic patients PCa.